“Depression is the toothpaste to the sweet orange juice that is life”

Brushing one’s teeth with toothpaste and then drinking orange juice results in an unpleasant taste, but it’s usually not fatal. “Toothpaste before orange juice equals death” is a one-line saying.
   
“Insomnia and depression is like toothpaste and orange juice” was posted on Twitter on October 23, 2014. “Depression is to a regular day as toothpaste is to orange juice” was posted on Twitter on April 19, 2017.
   
“Depression is the toothpaste to the sweet orange juice that is life” was posted on Reddit—Shower Thoughts on September 25, 2017.
   
     
Twitter 
babysitter‏
@aeromancy_
Insomnia and depression is like toothpaste and orange juice
7:13 PM - 23 Oct 2014 from Eastleigh, England
 
Twitter
Derr‏
@derrreed
Depression and winter are an even worse combination than orange juice and toothpaste.
8:25 PM - 21 Feb 2017
 
Twitter
Fictional Seviper‏
@fiction_seviper
Depression is to a regular day as toothpaste is to orange juice.
7:54 PM - 19 Apr 2017
 
Twitter
nadia‏
@nadia_3lizabeth
depression and gloomy rain days are like toothpaste and orange juice. i can’t take this shit anymore, guys, i need some sun.
8:41 AM - 8 May 2017
 
Twitter
Dick Narlton 🦉‏
@ncarlton69
Depression and stress combined is like orange juice and toothpaste 😒
1:18 AM - 18 Jun 2017 from Pocatello, ID
 
Reddit—Shower Thoughts
Depression is the toothpaste to the sweet orange juice that is life
submitted September 25, 2017 by xxTrafalgarLawxx
 
Twitter
Shower Thoughts‏
@atshower
Depression is the toothpaste to the sweet orange juice that is life
7:46 AM - 25 Sep 2017